Información del producto
PTPN22 antibody
Información adicional
Size
100µg
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Applications
ELISA, WB, IHC, IP
Target
PTPN22
Research Area
Signal Transduction, Metabolism
Form
liquid
Recomended Dilution
WB: 1:200-1:2000
Type Clonality
polyclonal
Immunogen
protein tyrosine phosphatase, non-receptor type 22(lymphoid)
Minimum Purity
≥95% as determined by SDS-PAGE
Synonyms
Tyrosine-protein phosphatase non-receptor type 22|Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP|Lymphoid phosphatase (LyP)|PEST-domain phosphatase (PEP)|PTPN22|PTPN8
Host
Rabbit
UniProt ID
Q9Y2R2
Gene ID
26191
Purification
Immunogen affinity purified
Iso type
IgG
Reactivity
Human, Mouse, Rat
Observed MW
79-95 kDa
Background
Acts as negative regulator of T-cell receptor(TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules(PubMed:16461343, PubMed:18056643).