Información del producto
SKIC8 antibody
Información adicional
Size
100µg
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Applications
ELISA, WB, IHC, IF
Target
SKIC8
Research Area
Cell Division and Proliferation
Form
liquid
Recomended Dilution
IF: 1:10-1:100
IHC: 1:20-1:200
IP: 1:500-1:5000
WB: 1:500-1:5000
IHC: 1:20-1:200
IP: 1:500-1:5000
WB: 1:500-1:5000
Type Clonality
polyclonal
Immunogen
WD repeat domain 61
Minimum Purity
≥95% as determined by SDS-PAGE
Synonyms
Superkiller complex protein 8 (Ski8)|Meiotic recombination REC14 protein homolog|WD repeat-containing protein 61|Superkiller complex protein 8, N-terminally processed Alternative names: WD repeat-containing protein 61, N-terminally processed|SKIC8|WDR61
Host
Rabbit
UniProt ID
Q9GZS3
Gene ID
80349
Purification
Immunogen affinity purified
Iso type
IgG
Reactivity
Human, Mouse, Rat
Observed MW
33 kDa
Background
Component of the PAF1 complex(PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through
UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates wit
it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 '
UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates wit
it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 '