Información del producto
UIMC1 antibody
Información adicional
Size
100µg
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Applications
ELISA, WB, IF, IHC,IF
Target
UIMC1
Research Area
Metabolism
Form
liquid
Recomended Dilution
IF: 1:10-1:100
IHC: 1:20-1:200
IP: 1:200-1:2000
WB: 1:200-1:1000
IHC: 1:20-1:200
IP: 1:200-1:2000
WB: 1:200-1:1000
Type Clonality
polyclonal
Immunogen
ubiquitin interaction motif containing 1
Minimum Purity
≥95% as determined by SDS-PAGE
Synonyms
BRCA1-A complex subunit RAP80|Receptor-associated protein 80|Retinoid X receptor-interacting protein 110|Ubiquitin interaction motif-containing protein 1|UIMC1|RAP80|RXRIP110
Host
Rabbit
UniProt ID
Q96RL1
Gene ID
51720
Purification
Immunogen affinity purified
Iso type
IgG
Reactivity
Human, Mouse
Observed MW
97 kDa, 80 kDa, 71-75 kDa, 61 kDa
Background
Ubiquitin-binding protein(PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin(PubMed:19328070, Ref.36). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DN
the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.
the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.