Información del producto
SH2B1 antibody
Información adicional
Size
100µg
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Applications
ELISA, WB, IP, IHC, IF
Target
SH2B1
Research Area
Signal Transduction
Form
liquid
Recomended Dilution
IF: 1:20-1:200
IHC: 1:20-1:200
IP: 1:200-1:2000
WB: 1:200-1:2000
IHC: 1:20-1:200
IP: 1:200-1:2000
WB: 1:200-1:2000
Type Clonality
polyclonal
Immunogen
SH2B adaptor protein 1
Minimum Purity
≥95% as determined by SDS-PAGE
Synonyms
SH2B adapter protein 1|Pro-rich, PH and SH2 domain-containing signaling mediator (PSM)|SH2 domain-containing protein 1B|SH2B1|KIAA1299|SH2B
Host
Rabbit
UniProt ID
Q9NRF2
Gene ID
25970
Purification
Immunogen affinity purified
Iso type
IgG
Reactivity
Human
Observed MW
79 kDa
Background
Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways mediated by Janus kinase(JAK) and receptor tyrosine kinases, including the receptors of insulin(INS), insulin-like growth factor I(IGF1), n
prolongs NGF-induced phosphorylation of AKT1 on 'Ser-473' and AKT1 enzymatic activity. Enhances the kinase activity of the cytokine receptor-associated tyrosine kinase JAK2 and of other receptor tyrosine kinases, such as FGFR3 and NTRK1. For JAK2, the mec
prolongs NGF-induced phosphorylation of AKT1 on 'Ser-473' and AKT1 enzymatic activity. Enhances the kinase activity of the cytokine receptor-associated tyrosine kinase JAK2 and of other receptor tyrosine kinases, such as FGFR3 and NTRK1. For JAK2, the mec