Información del producto
PSAP antibody
Información adicional
Size
100µg
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Applications
ELISA, WB, IHC
Target
PSAP
Research Area
Metabolism
Form
liquid
Recomended Dilution
IHC: 1:50 - 1:200
WB: 1:500 - 1:2000
WB: 1:500 - 1:2000
Type Clonality
polyclonal
Immunogen
prosaposin
Minimum Purity
≥95% as determined by SDS-PAGE
Synonyms
Prosaposin|Proactivator polypeptide|Saposin-A Alternative names: Protein A|Saposin-B-Val|Saposin-B Alternative names: Cerebroside sulfate activator (CSAct)|Dispersin|Sphingolipid activator protein 1 (SAP-1)|Sulfatide/GM1 activator|Saposin-C Alternative na
Host
Rabbit
UniProt ID
P07602
Gene ID
5660
Purification
Immunogen affinity purified
Iso type
IgG
Reactivity
Human, Mouse, Rat
Observed MW
60 kDa
Background
Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling.
Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase(EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase(EC 3.2.1.46). Saposin-C apparently acts by combining with the enzyme and acidic lipid to form
Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A(EC 3.1.6.8), GM1 gangliosides by beta-galactosidase(EC 3.2.1.23) and globotriaosylceramide by alpha-galactosidase A(EC 3.2.1.22). Saposin-B forms a solubilizing complex
Saposin-D is a specific sphingomyelin phosphodiesterase activator(EC 3.1.4.12).
Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases.
Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase(EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase(EC 3.2.1.46). Saposin-C apparently acts by combining with the enzyme and acidic lipid to form
Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A(EC 3.1.6.8), GM1 gangliosides by beta-galactosidase(EC 3.2.1.23) and globotriaosylceramide by alpha-galactosidase A(EC 3.2.1.22). Saposin-B forms a solubilizing complex
Saposin-D is a specific sphingomyelin phosphodiesterase activator(EC 3.1.4.12).
Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases.