Información del producto
OPTN antibody
Información adicional
Size
100µg
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Applications
ELISA, WB, IHC, IF
Target
OPTN
Research Area
Neuroscience, Immunology, Signal Transduction
Form
liquid
Recomended Dilution
IF: 1:50-1:500
IHC: 1:50-1:500
WB: 1:500-1:2000
IHC: 1:50-1:500
WB: 1:500-1:2000
Type Clonality
monoclonal
Immunogen
optineurin
Minimum Purity
≥95% as determined by SDS-PAGE
Synonyms
Optineurin|E3-14.7K-interacting protein (FIP-2)|Huntingtin yeast partner L|Huntingtin-interacting protein 7 (HIP-7)|Huntingtin-interacting protein L|NEMO-related protein|Optic neuropathy-inducing protein|Transcription factor IIIA-interacting protein (TFII
Host
Mouse
UniProt ID
Q96CV9
Gene ID
10133
Purification
Protein A+G purification
Clone Number
5F4
Iso type
IgG1
Reactivity
Human
Observed MW
66 kDa
Background
Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negativel
regulates Rab8 recruitnment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family
targets ubiquitin-coated bacteria(xenophagy), such as cytoplasmic Salmonella enterica, and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52. May constitute a cellular target for adenovirus E3 14.7, an inhibitor of TNF-alpha functions,
regulates Rab8 recruitnment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family
targets ubiquitin-coated bacteria(xenophagy), such as cytoplasmic Salmonella enterica, and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52. May constitute a cellular target for adenovirus E3 14.7, an inhibitor of TNF-alpha functions,