Información del producto
NRG1 antibody
Información adicional
Size
100µg
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Applications
ELISA, WB, IHC, IF, IP
Target
NRG1
Research Area
Signal Transduction, Cardiovascular, Immunology, Developmental biology, Neuroscience
Form
liquid
Recomended Dilution
IF: 1:50-1:500
IHC: 1:50-1:200 IP:1:500-1:2000
WB: 1:500-1:1000
IHC: 1:50-1:200 IP:1:500-1:2000
WB: 1:500-1:1000
Type Clonality
polyclonal
Immunogen
neuregulin 1
Minimum Purity
≥95% as determined by SDS-PAGE
Synonyms
Pro-neuregulin-1, membrane-bound isoform (Pro-NRG1)|Neuregulin-1 Alternative names: Acetylcholine receptor-inducing activity (ARIA)|Breast cancer cell differentiation factor p45|Glial growth factor|Heregulin (HRG)|Neu differentiation factor|Sensory and mo
Host
Rabbit
UniProt ID
Q02297
Gene ID
3084
Purification
Immunogen affinity purified
Iso type
IgG
Reactivity
Human, Mouse
Observed MW
55 kDa and 72 kDa
Background
Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions
implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4(PubMed:10867024, PubMed:7902537). Binds to ERBB3(PubMed:20682778). Acts as a
inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction
stimulating Schwann cell proliferation
stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells
implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4(PubMed:10867024, PubMed:7902537). Binds to ERBB3(PubMed:20682778). Acts as a
inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction
stimulating Schwann cell proliferation
stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells