Información del producto
CEP63 antibody
Información adicional
Size
100µg
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Applications
ELISA, WB, IF, IP, IHC
Target
CEP63
Research Area
Signal Transduction
Form
liquid
Recomended Dilution
IF: 1:20-1:200
IHC: 1:20-1:200
IP: 1:200-1:1000
WB: 1:500-1:2000
IHC: 1:20-1:200
IP: 1:200-1:1000
WB: 1:500-1:2000
Type Clonality
polyclonal
Immunogen
centrosomal protein 63 kDaa
Minimum Purity
≥95% as determined by SDS-PAGE
Synonyms
Centrosomal protein of 63 kDa (Cep63)|CEP63
Host
Rabbit
UniProt ID
Q96MT8
Gene ID
80254
Purification
Immunogen affinity purified
Iso type
IgG
Reactivity
Human, Mouse, Rat
Observed MW
57-75 kDa
Background
Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication
however, this function has been questioned(PubMed:21983783, PubMed:26297806). Also recruits CDK1 to centrosomes(PubMed:21406398). Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks(DSBs), is removed from centrosomes
the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Reported to be required for centrosomal recruitment of CEP152
this leads to the inactivation of spindle assembly and delay in mitotic progression(PubMed:21406398).
however, this function has been questioned(PubMed:21983783, PubMed:26297806). Also recruits CDK1 to centrosomes(PubMed:21406398). Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks(DSBs), is removed from centrosomes
the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Reported to be required for centrosomal recruitment of CEP152
this leads to the inactivation of spindle assembly and delay in mitotic progression(PubMed:21406398).