Información del producto
CBLC antibody
Información adicional
Size
100µg
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Applications
ELISA, WB
Target
CBLC
Research Area
Signal Transduction
Form
liquid
Recomended Dilution
WB: 1:500-1:2000
Type Clonality
polyclonal
Immunogen
Cas-Br-M(murine) ecotropic retroviral transforming sequence c
Minimum Purity
≥95% as determined by SDS-PAGE
Synonyms
E3 ubiquitin-protein ligase CBL-C|RING finger protein 57|RING-type E3 ubiquitin transferase CBL-C|SH3-binding protein CBL-3|SH3-binding protein CBL-C|Signal transduction protein CBL-C|CBLC|CBL3|RNF57
Host
Rabbit
UniProt ID
Q9ULV8
Gene ID
23624
Purification
Immunogen affinity purified
Iso type
IgG
Reactivity
Human, Mouse, Rat
Observed MW
52 kDa
Background
Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases U
CD2AP converts it from an inhibitor to a promoter of RET degradation
the function limits the potency of GDNF on neuronal survival.
upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by
CD2AP converts it from an inhibitor to a promoter of RET degradation
the function limits the potency of GDNF on neuronal survival.
upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by