Información del producto
Smad7 (Acetyl Lys70) rabbit pAb
Información adicional
Storage Conditions
-20°C/1 year
Applications
IHC
WB
WB
Concentration
1 mg/ml
Recomended Dilution
IHC-p 1:50-300
WB 1:500-2000
WB 1:500-2000
Type Clonality
Polyclonal
Immunogen
Synthesized peptide derived from human Smad7 (Acetyl Lys70)
Subcellular Location
Nucleus . Cytoplasm . Interaction with NEDD4L or RNF111 induces translocation from the nucleus to the cytoplasm (PubMed:16601693). TGF-beta stimulates its translocation from the nucleus to the cytoplasm. PDPK1 inhibits its translocation from the nucleus t
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Rat
Mouse
Rat
Human Gen
4092
Other Name
MAD homolog 8
Mothers against DPP homolog 7
Mothers against DPP homolog 8
Mothers against decapentaplegic homolog 7 (MAD homolog 7
Mothers against decapentaplegic homolog 8
SMAD 7
SMAD family member 7
Smad7
hSMAD7)
Mothers against DPP homolog 7
Mothers against DPP homolog 8
Mothers against decapentaplegic homolog 7 (MAD homolog 7
Mothers against decapentaplegic homolog 8
SMAD 7
SMAD family member 7
Smad7
hSMAD7)
Background
The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the en