Información del producto
c-Abl (phospho-Tyr89) rabbit pAb
Información adicional
Storage Conditions
-20°C/1 year
Applications
WB
Concentration
1 mg/ml
Recomended Dilution
WB 1:1000-2000
Type Clonality
Polyclonal
Immunogen
Synthesized phosho peptide around human c-Abl (Tyr89)
Subcellular Location
Cytoplasm, cytoskeleton. Nucleus. Mitochondrion . Shuttles between the nucleus and cytoplasm depending on environmental signals. Sequestered into the cytoplasm through interaction with 14-3-3 proteins. Localizes to mitochondria in response to oxidative st
Lipid-anchor. The myristoylated c-ABL protein is reported to be nuclear.
[Isoform IB]: Nucleus membrane
Lipid-anchor. The myristoylated c-ABL protein is reported to be nuclear.
[Isoform IB]: Nucleus membrane
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Rat
Mouse
Rat
Human Gen
25
Observed Band
140(200kd BCR-ABL complex）
Other Name
Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)
Background
22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR
MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [pr
This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 dom
MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [pr
This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 dom