Información del producto
Información adicional
Storage Conditions
-20°C/1 year
Applications
WB
Concentration
1 mg/ml
Recomended Dilution
WB 1：500-2000
Type Clonality
Polyclonal
Immunogen
Synthesized peptide derived from human DEN1A AA range: 14-64
Subcellular Location
Cytoplasmic vesicle, clathrin-coated vesicle membrane
Peripheral membrane protein . Cell junction, synapse, presynaptic cell membrane . Associates to membranes via lipid-binding activity. .
Peripheral membrane protein . Cell junction, synapse, presynaptic cell membrane . Associates to membranes via lipid-binding activity. .
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Mouse
Human Gen
57706
Background
Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase
see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010],
see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010],