Información del producto
HER2 (Phospho-Tyr1139) rabbit pAb
Información adicional
Storage Conditions
-20°C/1 year
Applications
IF
IHC
WB
IHC
WB
Concentration
1 mg/ml
Recomended Dilution
IHC-p 1:50-200, WB 1:500-2000
Type Clonality
Polyclonal
Immunogen
Synthesized peptide derived from human HER2 (Phospho-Tyr1139)
Subcellular Location
Single-pass type I membrane protein. Early endosome . Cytoplasm, perinuclear region. Nucleus. Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1. Also detected in VPS35-positive endosome-
[Isoform 1]: Cell membrane
[Isoform 2]: Cytoplasm. Nucleus.
[Isoform 3]: Cytoplasm. Nucleus.
[Isoform 1]: Cell membrane
[Isoform 2]: Cytoplasm. Nucleus.
[Isoform 3]: Cytoplasm. Nucleus.
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Rat
Mouse
Rat
Human Gen
2064
Observed Band
180kD
Other Name
CD antigen CD340)
MLN 19
Metastatic lymph node gene 19 protein
Proto-oncogene Neu
Proto-oncogene c-ErbB-2
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1
Tyrosine kinase-type cell surface receptor HER2
p185erbB2
MLN 19
Metastatic lymph node gene 19 protein
Proto-oncogene Neu
Proto-oncogene c-ErbB-2
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1
Tyrosine kinase-type cell surface receptor HER2
p185erbB2
Background
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-boun