Información del producto
Información adicional
Storage Conditions
-20°C/1 year
Applications
WB
Concentration
1 mg/ml
Recomended Dilution
WB 1:500-2000
Type Clonality
Polyclonal
Immunogen
Synthesized peptide derived from human PCSK6 AA range: 734-784
Subcellular Location
Peripheral membrane protein. Retained intracellularly probably through a hydrophobic cluster in their C-terminus.
Peripheral membrane protein. Retained intracellularly probably through a hydrophobic cluster in their C-terminus.
[Isoform PACE4A-II]: Secreted.
[Isoform PACE4A-I]: Secreted.
[Isoform PACE4B]: Secreted.
[Isoform PACE4CS]: Endoplasmic reticulum. Not secreted, remains probably in zymogen form in endoplasmic reticulum.
[Isoform PACE4C]: Endoplasmic reticulum. Not secreted, remains probably in zymogen form in endoplasmic reticulum.
[Isoform PACE4E-II]: Endomembrane system
[Isoform PACE4E-I]: Endomembrane system
Peripheral membrane protein. Retained intracellularly probably through a hydrophobic cluster in their C-terminus.
[Isoform PACE4A-II]: Secreted.
[Isoform PACE4A-I]: Secreted.
[Isoform PACE4B]: Secreted.
[Isoform PACE4CS]: Endoplasmic reticulum. Not secreted, remains probably in zymogen form in endoplasmic reticulum.
[Isoform PACE4C]: Endoplasmic reticulum. Not secreted, remains probably in zymogen form in endoplasmic reticulum.
[Isoform PACE4E-II]: Endomembrane system
[Isoform PACE4E-I]: Endomembrane system
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Rat
Rat
Human Gen
5046
Observed Band
105kD
Other Name
Proprotein convertase subtilisin/kexin type 6 (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin-like proprotein convertase 4) (SPC4) (Subtilisin/kexin-like protease PACE4)
Background
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein under