Storage Conditions
-20°C/1 year
Applications
IF
IHC
Concentration
1 mg/ml
Recomended Dilution
IHC-p 1:50-200
Type Clonality
Polyclonal
Immunogen
Synthesized peptide derived from human PEN2 AA range: 51-101
Subcellular Location
Endoplasmic reticulum membrane
Multi-pass membrane protein . Cell membrane
Multi-pass membrane protein . Golgi apparatus, Golgi stack membrane
Multi-pass membrane protein . Membrane
Multi-pass membrane protein . Predominantly located in the endoplasmic reticulum and in the cis-Golgi. .
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Rat
Human Gen
55851
Background
Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors me