Información del producto
Información adicional
Storage Conditions
-20°C/1 year
Applications
IF
IHC
WB
IHC
WB
Concentration
1 mg/ml
Recomended Dilution
IHC-p 1:50-200, WB 1:500-2000
Type Clonality
Polyclonal
Immunogen
Synthesized peptide derived from human Shh
Subcellular Location
Endoplasmic reticulum membrane . Golgi apparatus membrane . Co-localizes with HHAT in the ER and Golgi membrane. .
Lipid-anchor . The dual-lipidated sonic hedgehog protein N-product (ShhNp) is firmly tethered to the cell membrane where it forms multimers (PubMed:24522195). Further solubilization and release from the cell surface seem to be achieved through different m
[Sonic hedgehog protein N-product]: Cell membrane
Lipid-anchor . The dual-lipidated sonic hedgehog protein N-product (ShhNp) is firmly tethered to the cell membrane where it forms multimers (PubMed:24522195). Further solubilization and release from the cell surface seem to be achieved through different m
[Sonic hedgehog protein N-product]: Cell membrane
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Rat
Mouse
Rat
Human Gen
6469
Observed Band
40kD
Other Name
HHG-1) [Cleaved into: Sonic hedgehog protein N-product
Sonic hedgehog protein (SHH
Sonic hedgehog protein C-product]
Sonic hedgehog protein (SHH
Sonic hedgehog protein C-product]
Background
This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human protein
the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricti
the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricti