Storage Conditions
-20°C/1 year
Applications
WB
Concentration
1 mg/ml
Recomended Dilution
WB 1:500-2000
Type Clonality
Polyclonal
Immunogen
Synthesized peptide derived from human TNNC1 AA range: 57-107
Subcellular Location
nucleoplasm,mitochondrion,cytosol,troponin complex,actin cytoskeleton,contractile fiber,
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Human Gen
7134
Background
TnT, which contains the binding site for tropomyosin
Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase
and TnC, the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associate