Información del producto
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
WB
WB
Concentration
1 mg/ml
Recomended Dilution
WB 1:500-2000 ELISA 1:5000-20000
Type Clonality
Polyclonal
Immunogen
Synthesized peptide derived from part region of human protein
Subcellular Location
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton . Cell membrane . Cell projection, lamellipodium. Cell projection, ruffle. Nucleocytoplasmic shuttling protein
cytoplasmic in case of round cells, corresponding to the initial step of cell spreading, or nuclear in case of well spread cells. Colocalizes with ROCK1 and NME2 at beta-1 integrin engagement sites. Together with ITGB1 and NME2 is recruited to beta-1 inte
probably sequestered in the cytosol by ITGB1. Its localization is dependent on the stage of cell spreading on fibronectin
shuttles between nucleus and cytoplasm in a integrin-dependent manner
cytoplasmic in case of round cells, corresponding to the initial step of cell spreading, or nuclear in case of well spread cells. Colocalizes with ROCK1 and NME2 at beta-1 integrin engagement sites. Together with ITGB1 and NME2 is recruited to beta-1 inte
probably sequestered in the cytosol by ITGB1. Its localization is dependent on the stage of cell spreading on fibronectin
shuttles between nucleus and cytoplasm in a integrin-dependent manner
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Mouse
Human Gen
9270
Observed Band
22kD
Background
The cytoplasmic domains of integrins are essential for cell adhesion. The protein encoded by this gene binds to the beta1 integrin cytoplasmic domain. The interaction between this protein and beta1 integrin is highly specific. Two isoforms of this protein