Información del producto
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
IF
IHC
IF
IHC
Concentration
1 mg/ml
Recomended Dilution
IHC-p 1:50-200, ELISA 1:10000-20000
Type Clonality
Polyclonal
Immunogen
Synthetic peptide from human protein at AA range: 121-170
Subcellular Location
Cell membrane
Single-pass type II membrane protein . Cytoplasmic vesicle lumen . Lysosome lumen . Is internalized into multivesicular bodies of secretory lysosomes after phosphorylation by FGR and monoubiquitination (PubMed:17164290). Colocalizes with the SPPL2A protea
[FasL intracellular domain]: Nucleus . The FasL ICD cytoplasmic form is translocated into the nucleus. .
[Tumor necrosis factor ligand superfamily member 6, soluble form]: Secreted . May be released into the extracellular fluid by cleavage from the cell surface. .
Single-pass type II membrane protein . Cytoplasmic vesicle lumen . Lysosome lumen . Is internalized into multivesicular bodies of secretory lysosomes after phosphorylation by FGR and monoubiquitination (PubMed:17164290). Colocalizes with the SPPL2A protea
[FasL intracellular domain]: Nucleus . The FasL ICD cytoplasmic form is translocated into the nucleus. .
[Tumor necrosis factor ligand superfamily member 6, soluble form]: Secreted . May be released into the extracellular fluid by cleavage from the cell surface. .
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Rat
Mouse
Rat
Human Gen
356
Other Name
ADAM10-processed FasL form (APL)
APTL
CD95 ligand
CD95-L
CD antigen CD178) [Cleaved into: Tumor necrosis factor ligand superfamily member 6, membrane form
FasL
FasL intracellular domain (FasL ICD
Fas antigen ligand
Fas ligand
SPA)]
SPPL2A-processed FasL form
Soluble Fas ligand
Tumor necrosis factor ligand superfamily member 6 (Apoptosis antigen ligand
Tumor necrosis factor ligand superfamily member 6, soluble form (Receptor-binding FasL ectodomain
sFasL)
APTL
CD95 ligand
CD95-L
CD antigen CD178) [Cleaved into: Tumor necrosis factor ligand superfamily member 6, membrane form
FasL
FasL intracellular domain (FasL ICD
Fas antigen ligand
Fas ligand
SPA)]
SPPL2A-processed FasL form
Soluble Fas ligand
Tumor necrosis factor ligand superfamily member 6 (Apoptosis antigen ligand
Tumor necrosis factor ligand superfamily member 6, soluble form (Receptor-binding FasL ectodomain
sFasL)
Background
This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation,