Información del producto
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
IF
WB
IF
WB
Concentration
1 mg/ml
Recomended Dilution
ELISA 1:5000-20000
IF/ICC 1:100-500
WB 1:500-2000
IF/ICC 1:100-500
WB 1:500-2000
Type Clonality
Polyclonal
Immunogen
Synthesized peptide derived from Amyloid-β at AA range: 631-680
Subcellular Location
Cell membrane
Single-pass type I membrane protein . Membrane
Single-pass type I membrane protein . Perikaryon . Cell projection, growth cone . Membrane, clathrin-coated pit . Early endosome . Cytoplasmic vesicle . Cell surface protein that rapidly becomes internalized via clathrin-coated pits. Only a minor proporti
most of the protein is present in intracellular vesicles (PubMed:20580937). During maturation, the immature APP (N-glycosylated in the endoplasmic reticulum) moves to the Golgi complex where complete maturation occurs (O-glycosylated and sulfated). After
Single-pass type I membrane protein . Membrane
Single-pass type I membrane protein . Perikaryon . Cell projection, growth cone . Membrane, clathrin-coated pit . Early endosome . Cytoplasmic vesicle . Cell surface protein that rapidly becomes internalized via clathrin-coated pits. Only a minor proporti
most of the protein is present in intracellular vesicles (PubMed:20580937). During maturation, the immature APP (N-glycosylated in the endoplasmic reticulum) moves to the Golgi complex where complete maturation occurs (O-glycosylated and sulfated). After
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Rat
Mouse
Rat
Human Gen
351
Observed Band
86+45kD
Other Name
Amyloid beta A4 protein (ABPP) (APPI) (APP) (Alzheimer disease amyloid protein) (Cerebral vascular amyloid peptide) (CVAP) (PreA4) (Protease nexin-II) (PN-II) [Cleaved into: N-APP
Beta-amyloid protein 40 (Beta-APP40)
Beta-amyloid protein 42 (Beta-APP42)
C31]
C80
C83
C99
Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AICD-50) (AID(50)) (Gamma-CTF(50))
Gamma-secretase C-terminal fragment 57 (Amyloid intracellular domain 57) (AICD-57) (AID(57)) (Gamma-CTF(57))
Gamma-secretase C-terminal fragment 59 (Amyloid intracellular domain 59) (AICD-59) (AID(59)) (Gamma-CTF(59))
P3(40)
P3(42)
Soluble APP-alpha (S-APP-alpha)
Soluble APP-beta (S-APP-beta)
Beta-amyloid protein 40 (Beta-APP40)
Beta-amyloid protein 42 (Beta-APP42)
C31]
C80
C83
C99
Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AICD-50) (AID(50)) (Gamma-CTF(50))
Gamma-secretase C-terminal fragment 57 (Amyloid intracellular domain 57) (AICD-57) (AID(57)) (Gamma-CTF(57))
Gamma-secretase C-terminal fragment 59 (Amyloid intracellular domain 59) (AICD-59) (AID(59)) (Gamma-CTF(59))
P3(40)
P3(42)
Soluble APP-alpha (S-APP-alpha)
Soluble APP-beta (S-APP-beta)
Background
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptio