Información del producto
PRAK (phospho Thr182) rabbit pAb
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
IF
IHC
WB
IF
IHC
WB
Concentration
1 mg/ml
Recomended Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from human MAPKAPK5 around the phosphorylation site of Thr182. AA range:148-197
Subcellular Location
Cytoplasm. Nucleus. Translocates to the cytoplasm following phosphorylation and activation. Interaction with ERK3/MAPK6 or ERK4/MAPK4 and phosphorylation at Thr-182, activates the protein kinase activity, followed by translocation to the cytoplasm. Phosph
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Mouse
Human Gen
8550
Observed Band
60kD
Other Name
MAPK-activated protein kinase 5
MAPKAP-K5
MAPKAPK-5
MAPKAPK5
MAPKAP kinase 5
MAP kinase-activated protein kinase 5
MK-5
MK5
PRAK
PRAK
p38-regulated/activated protein kinase
MAPKAP-K5
MAPKAPK-5
MAPKAPK5
MAPKAP kinase 5
MAP kinase-activated protein kinase 5
MK-5
MK5
PRAK
PRAK
p38-regulated/activated protein kinase
Background
The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK,