Información del producto
LKB1 (phospho Ser428) rabbit pAb
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
IF
IHC
WB
IF
IHC
WB
Concentration
1 mg/ml
Recomended Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from human LKB1 around the phosphorylation site of Ser428. AA range:384-433
Subcellular Location
Nucleus. Cytoplasm. Membrane . Mitochondrion. A small fraction localizes at membranes (By similarity). Relocates to the cytoplasm when bound to STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta). Translocates to the mitochondrion
[Isoform 2]: Nucleus . Cytoplasm . Predominantly nuclear, but translocates to the cytoplasm in response to metformin or peroxynitrite treatment.
[Isoform 2]: Nucleus . Cytoplasm . Predominantly nuclear, but translocates to the cytoplasm in response to metformin or peroxynitrite treatment.
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Cow
Human
Mouse
Human
Mouse
Human Gen
6794
Observed Band
65kD
Other Name
LKB1
LKB1
Liver kinase B1
PJS
Renal carcinoma antigen NY-REN-19
STK11
Serine/threonine-protein kinase STK11
hLKB1
LKB1
Liver kinase B1
PJS
Renal carcinoma antigen NY-REN-19
STK11
Serine/threonine-protein kinase STK11
hLKB1
Background
This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by