SREBP-1 (phospho Ser439) rabbit pAb
  • SREBP-1 (phospho Ser439) rabbit pAb
ELK

SREBP-1 (phospho Ser439) rabbit pAb

Ref: ELK-ES7272-100μL
100μL

Información del producto

SREBP-1 (phospho Ser439) rabbit pAb

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Información adicional
Storage Conditions -20°C/1 year
Applications ELISA
IF
IHC
WB
Concentration 1 mg/ml
Recomended Dilution Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
Type Clonality Polyclonal
Immunogen The antiserum was produced against synthesized peptide derived from human SREBP-1 around the phosphorylation site of Ser439. AA range:405-454
Subcellular Location Multi-pass membrane protein . At high sterol concentrations, the SCAP-SREBP is retained in the endoplasmic reticulum. Low sterol concentrations promote recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi, where it is proces
Multi-pass membrane protein . Cytoplasmic vesicle, COPII-coated vesicle membrane
Multi-pass membrane protein . Golgi apparatus membrane
[Isoform SREBP-1aDelta]: Nucleus .
[Isoform SREBP-1cDelta]: Nucleus .
[Processed sterol regulatory element-binding protein 1]: Nucleus .
[Sterol regulatory element-binding protein 1]: Endoplasmic reticulum membrane
Iso type IgG
Tissue Source Rabbit
Reactivity Human
Rat
Human Gen 6720
Observed Band 122kD
Other Name BHLHD1
Class D basic helix-loop-helix protein 1
SREBF1
SREBP-1
SREBP1
Sterol regulatory element-binding protein 1
Sterol regulatory element-binding transcription factor 1
bHLHd1
Background This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor