Información del producto
BRCA1 (phospho Ser1423) rabbit pAb
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
IF
IHC
WB
IF
IHC
WB
Concentration
1 mg/ml
Recomended Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from human BRCA1 around the phosphorylation site of Ser1423. AA range:1391-1440
Subcellular Location
Nucleus . Chromosome . Cytoplasm . Localizes at sites of DNA damage at double-strand breaks (DSBs)
[Isoform 3]: Cytoplasm.
[Isoform 5]: Cytoplasm .
recruitment to DNA damage sites is mediated by ABRAXAS1 and the BRCA1-A complex (PubMed:26778126). Translocated to the cytoplasm during UV-induced apoptosis (PubMed:20160719). .
[Isoform 3]: Cytoplasm.
[Isoform 5]: Cytoplasm .
recruitment to DNA damage sites is mediated by ABRAXAS1 and the BRCA1-A complex (PubMed:26778126). Translocated to the cytoplasm during UV-induced apoptosis (PubMed:20160719). .
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Rat
Rat
Human Gen
672
Observed Band
210kD
Other Name
BRCA1
Breast cancer type 1 susceptibility protein
RING finger protein 53
RNF53
Breast cancer type 1 susceptibility protein
RING finger protein 53
RNF53
Background
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large mu