Información del producto
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
IF
IHC
WB
IF
IHC
WB
Concentration
1 mg/ml
Recomended Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from human UPF1. AA range:299-348
Subcellular Location
Cytoplasm . Cytoplasm, P-body. Nucleus . Cytoplasm, perinuclear region . Hyperphosphorylated form is targeted to the P-body, while unphosphorylated protein is distributed throughout the cytoplasm. Localized in the chromatoid bodies of round spermatids (By
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Mouse
Human Gen
5976
Observed Band
110kD
Other Name
ATP-dependent helicase RENT1
KIAA0221
NORF1
Nonsense mRNA reducing factor 1
RENT1
Regulator of nonsense transcripts 1
UPF1
Up-frameshift suppressor 1 homolog
hUpf1
KIAA0221
NORF1
Nonsense mRNA reducing factor 1
RENT1
Regulator of nonsense transcripts 1
UPF1
Up-frameshift suppressor 1 homolog
hUpf1
Background
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA d