Información del producto
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
IF
IHC
WB
IF
IHC
WB
Concentration
1 mg/ml
Recomended Dilution
ELISA 1:5000-20000
IF/ICC 1:100-500
IHC-p 1:100-500
WB 1:500-2000
IF/ICC 1:100-500
IHC-p 1:100-500
WB 1:500-2000
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from human Presenilin 1. AA range:1-50
Subcellular Location
Endoplasmic reticulum . Endoplasmic reticulum membrane
Multi-pass membrane protein . Cell projection, growth cone . Early endosome . Early endosome membrane
Multi-pass membrane protein . Cell projection, neuron projection . Cell projection, axon . Cell junction, synapse . Translocates with bound NOTCH1 from the endoplasmic reticulum and/or Golgi to the cell surface (PubMed:10593990). Colocalizes with CDH1/2 a
Multi-pass membrane protein . Cytoplasmic granule . Cell membrane
Multi-pass membrane protein . Golgi apparatus membrane
Multi-pass membrane protein . Cell projection, growth cone . Early endosome . Early endosome membrane
Multi-pass membrane protein . Cell projection, neuron projection . Cell projection, axon . Cell junction, synapse . Translocates with bound NOTCH1 from the endoplasmic reticulum and/or Golgi to the cell surface (PubMed:10593990). Colocalizes with CDH1/2 a
Multi-pass membrane protein . Cytoplasmic granule . Cell membrane
Multi-pass membrane protein . Golgi apparatus membrane
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Rat
Mouse
Rat
Human Gen
5663
Observed Band
60kD
Other Name
AD3
PS-1
PS1
PSEN1
PSNL1
Presenilin-1
Protein S182
PS-1
PS1
PSEN1
PSNL1
Presenilin-1
Protein S182
Background
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1
PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processi
PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processi