Información del producto
PAKγ (phospho Ser197) rabbit pAb
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
IF
IHC
IF
IHC
Concentration
1 mg/ml
Recomended Dilution
Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from human PAK2 around the phosphorylation site of Ser197. AA range:163-212
Subcellular Location
Lipid-anchor. Interaction with ARHGAP10 probably changes PAK-2p34 location to cytoplasmic perinuclear region. Myristoylation changes PAK-2p34 location to the membrane.
[PAK-2p34]: Nucleus. Cytoplasm, perinuclear region. Membrane
[Serine/threonine-protein kinase PAK 2]: Cytoplasm. MYO18A mediates the cellular distribution of the PAK2-ARHGEF7-GIT1 complex to the inner surface of the cell membrane.
[PAK-2p34]: Nucleus. Cytoplasm, perinuclear region. Membrane
[Serine/threonine-protein kinase PAK 2]: Cytoplasm. MYO18A mediates the cellular distribution of the PAK2-ARHGEF7-GIT1 complex to the inner surface of the cell membrane.
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Rat
Mouse
Rat
Human Gen
5062
Other Name
Gamma-PAK
PAK-2
PAK2
PAK65
S6/H4 kinase
Serine/threonine-protein kinase PAK 2
p21-activated kinase 2
p58
PAK-2
PAK2
PAK65
S6/H4 kinase
Serine/threonine-protein kinase PAK 2
p21-activated kinase 2
p58
Background
The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 an