Información del producto
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
IF
IHC
WB
IF
IHC
WB
Concentration
1 mg/ml
Recomended Dilution
Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from human Trk A. AA range:666-715
Subcellular Location
Cell membrane
Single-pass type I membrane protein . Early endosome membrane
Single-pass type I membrane protein . Late endosome membrane
Single-pass type I membrane protein . Rapidly internalized after NGF binding (PubMed:1281417). Internalized to endosomes upon binding of NGF or NTF3 and further transported to the cell body via a retrograde axonal transport. Localized at cell membrane and
Single-pass type I membrane protein . Recycling endosome membrane
Single-pass type I membrane protein . Early endosome membrane
Single-pass type I membrane protein . Late endosome membrane
Single-pass type I membrane protein . Rapidly internalized after NGF binding (PubMed:1281417). Internalized to endosomes upon binding of NGF or NTF3 and further transported to the cell body via a retrograde axonal transport. Localized at cell membrane and
Single-pass type I membrane protein . Recycling endosome membrane
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Rat
Mouse
Rat
Human Gen
4914
Observed Band
140-180kD
Other Name
High affinity nerve growth factor receptor
MTC
NTRK1
Neurotrophic tyrosine kinase receptor type 1
TRK
TRK1-transforming tyrosine kinase protein
TRKA
Tropomyosin-related kinase A
Tyrosine kinase receptor
Tyrosine kinase receptor A
MTC
NTRK1
Neurotrophic tyrosine kinase receptor type 1
TRK
TRK1-transforming tyrosine kinase protein
TRKA
Tropomyosin-related kinase A
Tyrosine kinase receptor
Tyrosine kinase receptor A
Background
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to ce