Información del producto
Tau (phospho Ser516/199) rabbit pAb
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
WB
WB
Concentration
1 mg/ml
Recomended Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from human Tau around the phosphorylation site of Ser516 or 199. AA range:166-215
Subcellular Location
Cytoplasm, cytosol . Cell membrane
Cytoplasmic side . Cytoplasm, cytoskeleton . Cell projection, axon . Cell projection, dendrite . Secreted . Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components (PubMed:10747907). Can be secreted
Peripheral membrane protein
it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059). .
the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10
Cytoplasmic side . Cytoplasm, cytoskeleton . Cell projection, axon . Cell projection, dendrite . Secreted . Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components (PubMed:10747907). Can be secreted
Peripheral membrane protein
it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059). .
the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Rat
Mouse
Rat
Human Gen
4137
Observed Band
50-85kD
Other Name
MAPT
MAPTL
MTBT1
Microtubule-associated protein tau
Neurofibrillary tangle protein
PHF-tau
Paired helical filament-tau
TAU
MAPTL
MTBT1
Microtubule-associated protein tau
Neurofibrillary tangle protein
PHF-tau
Paired helical filament-tau
TAU
Background
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stag