Información del producto
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
IF
IHC
WB
IF
IHC
WB
Concentration
1 mg/ml
Recomended Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from human CD91. AA range:4486-4535
Subcellular Location
Extracellular side. Membrane, coated pit.
Golgi outpost . Cytoplasm, cytoskeleton, microtubule organizing center . Localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, which shapes dendrite morphology by functioning as sites of acentrosomal microtubule nucleation. .
Peripheral membrane protein
Single-pass type I membrane protein. Membrane, coated pit.
[Low-density lipoprotein receptor-related protein 1 85 kDa subunit]: Cell membrane
[Low-density lipoprotein receptor-related protein 1 515 kDa subunit]: Cell membrane
[Low-density lipoprotein receptor-related protein 1 intracellular domain]: Cytoplasm . Nucleus . After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus. .
Golgi outpost . Cytoplasm, cytoskeleton, microtubule organizing center . Localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, which shapes dendrite morphology by functioning as sites of acentrosomal microtubule nucleation. .
Peripheral membrane protein
Single-pass type I membrane protein. Membrane, coated pit.
[Low-density lipoprotein receptor-related protein 1 85 kDa subunit]: Cell membrane
[Low-density lipoprotein receptor-related protein 1 515 kDa subunit]: Cell membrane
[Low-density lipoprotein receptor-related protein 1 intracellular domain]: Cytoplasm . Nucleus . After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus. .
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Mouse
Human Gen
4035
Observed Band
80kD
Other Name
A2MR
A2MR
APOER
APR
Alpha-2-macroglobulin receptor
Apolipoprotein E receptor
CD antigen CD91
LRP-1
LRP1
Prolow-density lipoprotein receptor-related protein 1
A2MR
APOER
APR
Alpha-2-macroglobulin receptor
Apolipoprotein E receptor
CD antigen CD91
LRP-1
LRP1
Prolow-density lipoprotein receptor-related protein 1
Background
This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is