Información del producto
IFN-α/βRα (phospho Tyr466) rabbit pAb
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
IF
IHC
WB
IF
IHC
WB
Concentration
1 mg/ml
Recomended Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from human Interferon-alpha/beta Receptor alpha around the phosphorylation site of Tyr466. AA range:436-485
Subcellular Location
Single-pass type I membrane protein . Late endosome . Lysosome . Interferon binding triggers internalization of the receptor from the cell membrane into endosomes and then into lysosomes. .
[Isoform 1]: Cell membrane
[Isoform 1]: Cell membrane
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Rat
Mouse
Rat
Human Gen
3454
Observed Band
63kD
Other Name
CRF2-1
Cytokine receptor class-II member 1
Cytokine receptor family 2 member 1
IFN-R-1
IFN-alpha/beta receptor 1
IFNAR
IFNAR1
Interferon alpha/beta receptor 1
Type I interferon receptor 1
Cytokine receptor class-II member 1
Cytokine receptor family 2 member 1
IFN-R-1
IFN-alpha/beta receptor 1
IFNAR
IFNAR1
Interferon alpha/beta receptor 1
Type I interferon receptor 1
Background
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several prote