Información del producto
Huntingtin (phospho Ser421) rabbit pAb
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
IF
IHC
IF
IHC
Concentration
1 mg/ml
Recomended Dilution
Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from human Huntingtin around the phosphorylation site of Ser421. AA range:387-436
Subcellular Location
[Huntingtin, myristoylated N-terminal fragment]: Cytoplasmic vesicle, autophagosome .
[Huntingtin]: Cytoplasm . Nucleus . Early endosome . The mutant Huntingtin protein colocalizes with AKAP8L in the nuclear matrix of Huntington disease neurons. Shuttles between cytoplasm and nucleus in a Ran GTPase-independent manner (PubMed:15654337). Re
[Huntingtin]: Cytoplasm . Nucleus . Early endosome . The mutant Huntingtin protein colocalizes with AKAP8L in the nuclear matrix of Huntington disease neurons. Shuttles between cytoplasm and nucleus in a Ran GTPase-independent manner (PubMed:15654337). Re
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Rat
Mouse
Rat
Human Gen
3064
Other Name
HD
HD protein
HTT
Huntingtin
Huntington disease protein
IT15
HD protein
HTT
Huntingtin
Huntington disease protein
IT15
Background
huntingtin(HTT) Homo sapiens Huntingtin is a disease gene linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingt