Información del producto
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
IF
IHC
WB
IF
IHC
WB
Concentration
1 mg/ml
Recomended Dilution
Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from human Ubinuclein. AA range:161-210
Subcellular Location
Nucleus, nucleoplasm. Nucleus, PML body. Cell junction, tight junction. Localized as a nuclear speckled-like pattern in proliferating primary fibroblasts. Colocalizes with HIRA, PML and SP100 in PML bodies of senescent cells. Colocalizes with TJP1 and CLD
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Mouse
Human Gen
29855
Other Name
HIRA-binding protein
Protein VT4
UBN1
Ubinuclein-1
Ubiquitously expressed nuclear protein
Protein VT4
UBN1
Ubinuclein-1
Ubiquitously expressed nuclear protein
Background
function:Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for repl
the interaction is direct. Interacts with ASF1A, CEBPA, TJP1, TJP2 and TJP3.,tissue specificity:Ubiquitous. Also expressed in numerous tumors and cancer cell lines.,
the interaction is direct. Interacts with ASF1A, CEBPA, TJP1, TJP2 and TJP3.,tissue specificity:Ubiquitous. Also expressed in numerous tumors and cancer cell lines.,