Información del producto
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
IF
IHC
WB
IF
IHC
WB
Concentration
1 mg/ml
Recomended Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from human FOXC1/2. AA range:151-200
Subcellular Location
Nucleus . Colocalizes with PITX2 isoform 3 in the nucleus at subnuclear chromatine regions (PubMed:16449236). Colocalizes with CBX5 to a heterochromatin-rich region of the nucleus (PubMed:15684392). Colocalizes with GLI2 in the nucleus (By similarity). .
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Rat
Mouse
Rat
Human Gen
2296/2303
Observed Band
57kD
Other Name
FKHL7
FKHL14
FOXC1
FOXC2
FREAC-3
FREAC3
Forkhead-related protein FKHL7
Forkhead-related protein FKHL14
Forkhead-related transcription factor 3
Forkhead box protein C1
Forkhead box protein C2
MFH1
Mesenchyme fork head protein 1
FKHL14
FOXC1
FOXC2
FREAC-3
FREAC3
Forkhead-related protein FKHL7
Forkhead-related protein FKHL14
Forkhead-related transcription factor 3
Forkhead box protein C1
Forkhead box protein C2
MFH1
Mesenchyme fork head protein 1
Background
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined
however, it has been shown to play a role in the regulation of embryonic and ocular development. Mutations in this gene cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld
however, it has been shown to play a role in the regulation of embryonic and ocular development. Mutations in this gene cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld