Información del producto
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
IF
IHC
WB
IF
IHC
WB
Concentration
1 mg/ml
Recomended Dilution
Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000,WB 1:500-2000
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from human HER4. AA range:1250-1299
Subcellular Location
Cell membrane
Single-pass type I membrane protein . In response to NRG1 treatment, the activated receptor is internalized.
[ERBB4 intracellular domain]: Nucleus . Mitochondrion . Following proteolytical processing E4ICD (E4ICD1 or E4ICD2 generated from the respective isoforms) is translocated to the nucleus. Significantly more E4ICD2 than E4ICD1 is found in the nucleus. E4ICD
Single-pass type I membrane protein . In response to NRG1 treatment, the activated receptor is internalized.
[ERBB4 intracellular domain]: Nucleus . Mitochondrion . Following proteolytical processing E4ICD (E4ICD1 or E4ICD2 generated from the respective isoforms) is translocated to the nucleus. Significantly more E4ICD2 than E4ICD1 is found in the nucleus. E4ICD
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Rat
Mouse
Rat
Human Gen
2066
Other Name
ERBB4
HER4
Proto-oncogene-like protein c-ErbB-4
Receptor tyrosine-protein kinase erbB-4
Tyrosine kinase-type cell surface receptor HER4
p180erbB4
HER4
Proto-oncogene-like protein c-ErbB-4
Receptor tyrosine-protein kinase erbB-4
Tyrosine kinase-type cell surface receptor HER4
p180erbB4
Background
This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotid
however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008],
however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008],