Información del producto
Eps15 (phospho Tyr849) rabbit pAb
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
WB
WB
Concentration
1 mg/ml
Recomended Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
Synthesized phospho-peptide around the phosphorylation site of human Eps15 (phospho Tyr849)
Subcellular Location
Cytoplasm. Cell membrane
Cytoplasmic side . Colocalizes with HGS on bilayered clathrin coats on endosomes.
Cytoplasmic side. Membrane, clathrin-coated pit. Recruited to the plasma membrane upon EGFR activation and localizes to coated pits. Colocalizes with UBQLN1 in ubiquitin-rich cytoplasmic aggregates that are not endocytic compartments and in cytoplasmic ju
Peripheral membrane protein
Peripheral membrane protein
[Isoform 2]: Early endosome membrane
Cytoplasmic side . Colocalizes with HGS on bilayered clathrin coats on endosomes.
Cytoplasmic side. Membrane, clathrin-coated pit. Recruited to the plasma membrane upon EGFR activation and localizes to coated pits. Colocalizes with UBQLN1 in ubiquitin-rich cytoplasmic aggregates that are not endocytic compartments and in cytoplasmic ju
Peripheral membrane protein
Peripheral membrane protein
[Isoform 2]: Early endosome membrane
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Rat
Mouse
Rat
Human Gen
2060
Observed Band
100kD
Other Name
AF1P
EPS15
Epidermal growth factor receptor substrate 15
Protein AF-1p
Protein Eps15
EPS15
Epidermal growth factor receptor substrate 15
Protein AF-1p
Protein Eps15
Background
This gene encodes a protein that is part of the EGFR pathway. The protein is present at clatherin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemi