Información del producto
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
IF
WB
IF
WB
Concentration
1 mg/ml
Recomended Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from the C-terminal region of human IGF2R. AA range:2251-2300
Subcellular Location
Golgi apparatus membrane
Single-pass type I membrane protein . Endosome membrane
Single-pass type I membrane protein . Mainly localized in the Golgi at steady state and not detectable in lysosome (PubMed:18817523). Colocalized with DPP4 in internalized cytoplasmic vesicles adjacent to the cell surface (PubMed:10900005). .
Single-pass type I membrane protein . Endosome membrane
Single-pass type I membrane protein . Mainly localized in the Golgi at steady state and not detectable in lysosome (PubMed:18817523). Colocalized with DPP4 in internalized cytoplasmic vesicles adjacent to the cell surface (PubMed:10900005). .
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Rat
Mouse
Rat
Human Gen
3482
Observed Band
250kD
Other Name
300 kDa mannose 6-phosphate receptor
CD222
CI-MPR
CI Man-6-P receptor
Cation-independent mannose-6-phosphate receptor
IGF-II receptor
IGF2R
Insulin-like growth factor 2 receptor
Insulin-like growth factor II receptor
M6P/IGF2 receptor
M6P/IGF2R
M6PR
MPR 300
MPRI
CD222
CI-MPR
CI Man-6-P receptor
Cation-independent mannose-6-phosphate receptor
IGF-II receptor
IGF2R
Insulin-like growth factor 2 receptor
Insulin-like growth factor II receptor
M6P/IGF2 receptor
M6P/IGF2R
M6PR
MPR 300
MPRI
Background
This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking
however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611). [provided by RefSeq, Nov 2015],
however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611). [provided by RefSeq, Nov 2015],