Información del producto
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
IF
IHC
WB
IF
IHC
WB
Concentration
1 mg/ml
Recomended Dilution
Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human PDIA3. AA range:111-160
Subcellular Location
Endoplasmic reticulum . Endoplasmic reticulum lumen . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545). .
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Rat
Mouse
Rat
Human Gen
2923
Observed Band
55kD
Other Name
58 kDa glucose-regulated protein
58 kDa microsomal protein
Disulfide isomerase ER-60
ERP57
ERP60
ERp57
ERp60
ER protein 57
ER protein 60
Endoplasmic reticulum resident protein 57
Endoplasmic reticulum resident protein 60
GRP58
PDIA3
Protein disulfide-isomerase A3
p58
58 kDa microsomal protein
Disulfide isomerase ER-60
ERP57
ERP60
ERp57
ERp60
ER protein 57
ER protein 60
Endoplasmic reticulum resident protein 57
Endoplasmic reticulum resident protein 60
GRP58
PDIA3
Protein disulfide-isomerase A3
p58
Background
This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase
however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrat
however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrat