Información del producto
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
IF
IHC
WB
IF
IHC
WB
Concentration
1 mg/ml
Recomended Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from human Uba2. AA range:591-640
Subcellular Location
Cytoplasm. Nucleus. Shuttles between the cytoplasm and the nucleus, sumoylation is required either for nuclear translocation or nuclear retention.
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Rat
Mouse
Rat
Human Gen
10054
Observed Band
71kD
Other Name
Anthracycline-associated resistance ARX
HRIHFB2115
SAE2
SUMO-activating enzyme subunit 2
UBA2
UBLE1B
Ubiquitin-like 1-activating enzyme E1B
HRIHFB2115
SAE2
SUMO-activating enzyme subunit 2
UBA2
UBLE1B
Ubiquitin-like 1-activating enzyme E1B
Background
MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 (MIM 613294) and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[suppli
Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1
Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1