Storage Conditions
-20°C/1 year
Applications
ELISA
WB
Concentration
1 mg/ml
Recomended Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from human RUNX3. AA range:133-182
Subcellular Location
Nucleus . Cytoplasm . The tyrosine phosphorylated form localizes to the cytoplasm. Translocates from the cytoplasm to the nucleus following TGF-beta stimulation. .
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Human Gen
864
Observed Band
44kD
Other Name
AML2
Acute myeloid leukemia 2 protein
CBF-alpha-3
CBFA3
Core-binding factor subunit alpha-3
Oncogene AML-2
PEA2-alpha C
PEB
PEBP2A3
Polyomavirus enhancer-binding protein 2 alpha C subunit
RUNX3
Runt-related transcription factor 3
Background
This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and