Información del producto
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
IF
IHC
WB
IF
IHC
WB
Concentration
1 mg/ml
Recomended Dilution
IF: 1:50-200 Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunocytochemistry: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from human Rock-1. AA range:262-311
Subcellular Location
Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Golgi apparatus membrane
Peripheral membrane protein . Cell projection, bleb . Cytoplasm, cytoskeleton . Cell membrane . Cell projection, lamellipodium . Cell projection, ruffle . A small proportion is associated with Golgi membranes (PubMed:12773565). Associated with the mother
Peripheral membrane protein . Cell projection, bleb . Cytoplasm, cytoskeleton . Cell membrane . Cell projection, lamellipodium . Cell projection, ruffle . A small proportion is associated with Golgi membranes (PubMed:12773565). Associated with the mother
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Monkey
Mouse
Rat
Monkey
Mouse
Rat
Human Gen
6093
Observed Band
158kD
Other Name
ROCK-I
ROCK1
Renal carcinoma antigen NY-REN-35
Rho-associated
Rho-associated, coiled-coil-containing protein kinase I
Rho-associated protein kinase 1
coiled-coil-containing protein kinase 1
p160 ROCK-1
p160ROCK
ROCK1
Renal carcinoma antigen NY-REN-35
Rho-associated
Rho-associated, coiled-coil-containing protein kinase I
Rho-associated protein kinase 1
coiled-coil-containing protein kinase 1
p160 ROCK-1
p160ROCK
Background
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets a