Información del producto
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
IF
IHC
WB
IF
IHC
WB
Concentration
1 mg/ml
Recomended Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from human CBF beta. AA range:11-60
Subcellular Location
Nucleus .
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Rat
Mouse
Rat
Human Gen
865
Observed Band
22kD
Other Name
CBF-beta
CBFB
Core-binding factor subunit beta
PEA2-beta
PEBP2-beta
Polyomavirus enhancer-binding protein 2 beta subunit
SL3-3 enhancer factor 1 subunit beta
SL3/AKV core-binding factor beta subunit
CBFB
Core-binding factor subunit beta
PEA2-beta
PEBP2-beta
Polyomavirus enhancer-binding protein 2 beta subunit
SL3-3 enhancer factor 1 subunit beta
SL3/AKV core-binding factor beta subunit
Background
The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesi
it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing
it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing