Información del producto
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
IF
IHC
WB
IF
IHC
WB
Concentration
1 mg/ml
Recomended Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from human ARC. AA range:159-208
Subcellular Location
Lipid-anchor . Phosphorylation at Thr-149 results in translocation to mitochondria. Colocalized with mitochondria in response to oxidative stress. .
[Isoform 1]: Nucleus, nucleolus . The SR-rich C-terminus mediates nuclear localization. .
[Isoform 2]: Cytoplasm . Mitochondrion . Sarcoplasmic reticulum . Membrane
[Isoform 3]: Cytoplasm .
[Isoform 1]: Nucleus, nucleolus . The SR-rich C-terminus mediates nuclear localization. .
[Isoform 2]: Cytoplasm . Mitochondrion . Sarcoplasmic reticulum . Membrane
[Isoform 3]: Cytoplasm .
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Rat
Mouse
Rat
Human Gen
8996
Observed Band
28kD
Other Name
Myp
NOL3
Nop30
Nucleolar protein 3
apoptosis repressor ARC
apoptosis repressor with CARD
apoptosis repressor with caspase recruitment domain (CARD)
muscle-enriched cytoplasmic protein
nucleolar protein of 30 kDa
NOL3
Nop30
Nucleolar protein 3
apoptosis repressor ARC
apoptosis repressor with CARD
apoptosis repressor with caspase recruitment domain (CARD)
muscle-enriched cytoplasmic protein
nucleolar protein of 30 kDa
Background
NOL3 encodes an anti-apoptotic protein nucleolar protein 3 that has been shown to down-regulate the enzyme activities of caspase 2, caspase 8 and tumor protein p53. Multiple transcript variants encoding different isoforms have been found for NOL3.