Información del producto
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
IHC
WB
IHC
WB
Concentration
1 mg/ml
Recomended Dilution
ELISA 2000-20000
IHC-p 1:50-300
WB 1:500-2000
IHC-p 1:50-300
WB 1:500-2000
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from human JMY. AA range:931-980
Subcellular Location
Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane . Localizes to the nucleus in most cell types. Accumulates in nucleus under DNA damage conditions, increasing p53/TP53 transcription response and reducing its influence on cell motility (By similar
Nucleus . Cytoplasmic vesicle . Cytoplasm, cytoskeleton . Endomembrane system
Nucleus . Cytoplasmic vesicle . Cytoplasm, cytoskeleton . Endomembrane system
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Mouse
Human Gen
133746
Observed Band
130kD
Other Name
JMY
Junction-mediating and -regulatory protein
Junction-mediating and -regulatory protein
Background
function:Cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage.,induction:By E2F.,PTM:Ubiquitina