Información del producto
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
WB
WB
Concentration
1 mg/ml
Recomended Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from human HLA-DOB. AA range:1-50
Subcellular Location
Endosome membrane
Single-pass type I membrane protein. Complexes with HLA-DM molecule during intracellular transport and in endosomal/lysosomal compartments. Heterotetramerization is necessary to exit the ER.
Single-pass type I membrane protein. Lysosome membrane
Single-pass type I membrane protein. Complexes with HLA-DM molecule during intracellular transport and in endosomal/lysosomal compartments. Heterotetramerization is necessary to exit the ER.
Single-pass type I membrane protein. Lysosome membrane
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Human Gen
3112
Observed Band
30kD
Other Name
DO beta chain
HLA-DOB
HLA class II histocompatibility antigen
MHC class II antigen DOB
HLA-DOB
HLA class II histocompatibility antigen
MHC class II antigen DOB
Background
HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading o