Información del producto
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
IF
IHC
WB
IF
IHC
WB
Concentration
1 mg/ml
Recomended Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from human HLA-DOA. AA range:71-120
Subcellular Location
Endosome membrane
Single-pass type I membrane protein. Complexes with HLA-DM molecule during intracellular transport and in endosomal/lysosomal compartments. Heterotetramerization is necessary to exit the ER.
Single-pass type I membrane protein. Lysosome membrane
Single-pass type I membrane protein. Complexes with HLA-DM molecule during intracellular transport and in endosomal/lysosomal compartments. Heterotetramerization is necessary to exit the ER.
Single-pass type I membrane protein. Lysosome membrane
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Human Gen
3111
Observed Band
34kD
Other Name
DO alpha chain
HLA-DNA
HLA-DOA
HLA-DZA
HLA class II histocompatibility antigen
MHC DN-alpha
MHC DZ alpha
MHC class II antigen DOA
HLA-DNA
HLA-DOA
HLA-DZA
HLA class II histocompatibility antigen
MHC DN-alpha
MHC DZ alpha
MHC class II antigen DOA
Background
HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with cla