Información del producto
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
IF
IHC
WB
IF
IHC
WB
Concentration
1 mg/ml
Recomended Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from human FEN1. AA range:86-135
Subcellular Location
[Isoform 1]: Nucleus, nucleolus. Nucleus, nucleoplasm. Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.
[Isoform FENMIT]: Mitochondrion .
[Isoform FENMIT]: Mitochondrion .
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Rat
Mouse
Rat
Human Gen
2237
Observed Band
42kD
Other Name
DNase IV
FEN-1
FEN1
Flap endonuclease 1
Flap structure-specific endonuclease 1
MF1
Maturation factor 1
RAD2
hFEN-1
FEN-1
FEN1
Flap endonuclease 1
Flap structure-specific endonuclease 1
MF1
Maturation factor 1
RAD2
hFEN-1
Background
The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excis