Información del producto
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
IF
IHC
WB
IF
IHC
WB
Concentration
1 mg/ml
Recomended Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from human Estrogen Receptor-alpha. AA range:501-550
Subcellular Location
Cytoplasmic side . A minor fraction is associated with the inner membrane.
Cytoplasmic side. Cell membrane
Nucleus. Golgi apparatus. Cell membrane. Colocalizes with ZDHHC7 and ZDHHC21 in the Golgi apparatus where most probably palmitoylation occurs. Associated with the plasma membrane when palmitoylated.
Peripheral membrane protein
Peripheral membrane protein
Single-pass type I membrane protein. Associated with the inner membrane via palmitoylation (Probable). At least a subset exists as a transmembrane protein with a N-terminal extracellular domain. .
[Isoform 1]: Nucleus . Cytoplasm . Cell membrane
[Isoform 3]: Nucleus. Cytoplasm. Cell membrane
Cytoplasmic side. Cell membrane
Nucleus. Golgi apparatus. Cell membrane. Colocalizes with ZDHHC7 and ZDHHC21 in the Golgi apparatus where most probably palmitoylation occurs. Associated with the plasma membrane when palmitoylated.
Peripheral membrane protein
Peripheral membrane protein
Single-pass type I membrane protein. Associated with the inner membrane via palmitoylation (Probable). At least a subset exists as a transmembrane protein with a N-terminal extracellular domain. .
[Isoform 1]: Nucleus . Cytoplasm . Cell membrane
[Isoform 3]: Nucleus. Cytoplasm. Cell membrane
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Rat
Mouse
Rat
Human Gen
2099
Observed Band
66kD
Other Name
ER
ER-alpha
ESR
ESR1
Estradiol receptor
Estrogen receptor
NR3A1
Nuclear receptor subfamily 3 group A member 1
ER-alpha
ESR
ESR1
Estradiol receptor
Estrogen receptor
NR3A1
Nuclear receptor subfamily 3 group A member 1
Background
This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or