Información del producto
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
IF
WB
IF
WB
Concentration
1 mg/ml
Recomended Dilution
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from human S1P Receptor EDG1. AA range:206-255
Subcellular Location
Cell membrane
Multi-pass membrane protein. Endosome. Membrane raft. Recruited to caveolin-enriched plasma membrane microdomains in response to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine. Ligand binding leads to receptor internalization.
Multi-pass membrane protein. Endosome. Membrane raft. Recruited to caveolin-enriched plasma membrane microdomains in response to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine. Ligand binding leads to receptor internalization.
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Mouse
Rat
Mouse
Rat
Human Gen
1901
Observed Band
50kD
Other Name
CD antigen CD363
CHEDG1
EDG1
Endothelial differentiation G-protein coupled receptor 1
S1P1
S1PR1
S1P receptor 1
S1P receptor Edg-1
Sphingosine 1-phosphate receptor 1
Sphingosine 1-phosphate receptor Edg-1
CHEDG1
EDG1
Endothelial differentiation G-protein coupled receptor 1
S1P1
S1PR1
S1P receptor 1
S1P receptor Edg-1
Sphingosine 1-phosphate receptor 1
Sphingosine 1-phosphate receptor Edg-1
Background
The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the