Información del producto
Información adicional
Storage Conditions
-20°C/1 year
Applications
ELISA
IF
IHC
WB
IF
IHC
WB
Concentration
1 mg/ml
Recomended Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Type Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from human Cytochrome P450 2D6. AA range:251-300
Subcellular Location
Endoplasmic reticulum membrane
Peripheral membrane protein.
Peripheral membrane protein. Microsome membrane
Peripheral membrane protein.
Peripheral membrane protein. Microsome membrane
Iso type
IgG
Tissue Source
Rabbit
Reactivity
Human
Human Gen
1565
Observed Band
55kD
Other Name
CYP2D6
CYP2DL1
CYPIID6
Cytochrome P450 2D6
Cytochrome P450-DB1
Debrisoquine 4-hydroxylase
CYP2DL1
CYPIID6
Cytochrome P450 2D6
Cytochrome P450-DB1
Debrisoquine 4-hydroxylase
Background
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein local
certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Some individuals with the poor metabolizer phenotype have no functional protein since they carry 2 null alleles whereas i
certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Some individuals with the poor metabolizer phenotype have no functional protein since they carry 2 null alleles whereas i